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Observe Closely (2)pentobarbital will lessen the extent or result of suvorexant by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Watch. Solid CYP3A4 inducers may perhaps decrease suvorexant efficacy; if enhanced suvorexant dose expected, never exceed 20 mg/working daypentobarbital will decrease the level or result of elbasvir/g